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. Author manuscript; available in PMC: 2012 Jul 18.
Published in final edited form as: Sci Transl Med. 2012 Jan 18;4(117):117ra8. doi: 10.1126/scitranslmed.3002670

Figure 7. Model for AVM regression: normalization of arteriovenous programming elicited by repression of Notch4* initiates AVM narrowing.

Figure 7

(A) In control mice, Notch and ephrin-B2 are expressed in arteries and into capillaries. Coup-TFII and EphB4 are expressed in veins, and into capillaries. (B) In mutant mice, Notch4* is forcibly expressed throughout the endothelium, causing the repression of EphB4, and the expression of ephrin-B2 through AV shunts. The venous marker Coup-TFII, upstream of Notch, is retained, demarcating the original arterial venous boundary. (C) Repression of Notch4* allows EphB4 to be re-expressed in Coup-TFII+ venous segment. Normalization of Ephrin-B2/EphB4 signaling in the AV cell interface results in reorganization of endothelial cells, initiating the AV shunt narrowing and AVM regression.