Table 1.
Key Studies of Association of Stress Hyperglycemia and Mortality in Critically Ill Children
| Study (number denotes study reference) | Setting/patient population | Sample size | Definition of SH | Mortality associated with SH | |
|---|---|---|---|---|---|
| OR/RR | 95% CI | ||||
| Srinivasan1 | ICU | 152 | BG ≥150 mg/dl (≥8.3 mmol/liter) | OR 3.4 | 1.4–8.6 |
| Faustino2 | ICU | 942 | BG ≥150 mg/dl (≥8.3 mmol/liter) | RR 2.5 | 1.3–4.9 |
| Wintergerst3 | ICU | 1094 | BG >150 mg/dl (>8.3 mmol/liter) | RR 4.8 | 1.2–19.5 |
| Yung4 | ICU | 409 | BG >126 mg/dl (>7.0 mmol/liter) | OR 3.1 | 1.3–7.7 |
| Hirshberg5 | ICU | 863 | BG ≥150 mg/dl (≥8.3 mmol/liter) | OR 11.1 | 1.5–85.6 |
| Gore10 | Burns | 58 | BG ≥140 mg/dl (≥7.8 mmol/liter) | RR 5.1 | 2.1–12.7 |
| Michaud12 | Traumatic brain injury | 54 | BG ≥250 mg/dl (≥13.9 mmol/liter) | OR 8.3 | 1.3–53.6 |
| Branco13 | Septic shock | 57 | BG >178 mg/dl (>9.9 mmol/liter) | RR 2.6 | 1.4–4.9 |
| Yates14 | Cardiac surgery | 184 | BG ≥126 mg/dl (≥7.0 mmol/liter) | OR 1.5 | Not specified |
RR, relative risk; OR, odds ratio; CI, confidence interval