Figure 4.

Individualized prediction models of TG and FFAs during lipid infusion. (A) Plots of directly measured vs predicted plasma TG and FFA concentrations in 15 healthy young adults. A total of 12 breath and room air samples were taken for each subject during a 4-h lipid infusion study, which resulted in a ∼2.5-fold increase of plasma lipids above basal levels. Individualized prediction models based on multilinear regression analyses of 4-VOC clusters (2-PeONO₂, CO₂, CH₃ONO₂, and toluene for TGs, left; 2-pentanone, 2-PeONO₂, butanone, MTBE for FFAs, right) demonstrated the highest overall correlation with directly measured lipid concentrations. (B) Time course of measured and predicted lipid values in two representative subjects.