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. 2010 Nov 30;117(4):1408–1414. doi: 10.1182/blood-2010-07-299099

Figure 2.

Figure 2

aPL antibodies and a murine monoclonal anti-β2GPI antibody (E7) increase carotid artery and peritoneal macrophages TF activity in mice through an interaction with ApoER2. ApoER2+/+ (filled bars) or ApoER2−/− (open bars) mice were injected with either IgG-NHS, IgG-APS, IgG MoAbC, or E7. Carotid arteries (A) or peritoneal macrophages (B) were harvested from ApoER2+/+ or ApoER2−/− mice, and TF activity in homogenates was determined with a commercial chromogenic assay for Xa formation. At least 3 animals were used per condition. Results are expressed as pM · mg−1 · mL−1 ± SEM. An unpaired t test was applied to examine statistical significance. ¶Statistically different from apoER2+/+ treated with control; (A) NHS (P = .014) or MuMoAb (P = .003) and (B) NHS (P = .004) or MuMoAb (P = .003). *Statistically different from apoER2+/+ treated with IgG-APS (A, P = .009 and B, P < .0001) or E7 (A, P < .0001 and B, P = .018). **Statistically different from apoER2−/− treated with IgG-APS (A, P = < .0001 and B, P = .040) or E7 (A, P = .030 and B, P = .0004).