Table 1.
Mean and standard deviations of confounding variables measured over time at different time points during the experiment are represented. P value was obtained by analysis using repeated measures ANOVA.
| Control Group (Mean and Standard deviation) |
Surfactant Group (Mean and Standard deviation) |
||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T-BL | T-0 | T-0.5 | T-1 | T-1.5 | T-2 | T-2.5 | T-3 | End | T-BL | T-0 | T-0.5 | T-1 | T-1.5 | T-2 | T-2.5 | T-3 | End | P value | |
| Temp (°C) | 36.8 (0.6) | 36.7 (0.4) | 36.6 (0.6) | 36.6 (0.6) | 36.7 (0.6) | 36.7 (0.7) | 36.7 (0.8) | 36.8 (0.8) | 36.9 (0.8) | 36.6 (0.7) | 36.5 (0.7) | 36.6 (0.7) | 36.7 (0.7) | 35.8 (2.6) | 36.8 (0.8) | 36.8 (0.6) | 36.6 (0.5) | 36.4 (0.5) | 0.46 |
| MAP (mm Hg) | 73 (7.9) | 77 (11.2) | 80 (8.2) | 80 (9.6) | 79 (9.5) | 74 (8.4) | 74 (5.6) | 72 (6.7) | 68 (4.7) | 75 (10) | 86 (13.7) | 81 (13.5) | 79 (12.5) | 79 (12.4) | 78 (11.7) | 77 (11.4) | 75 (8.6) | 71 (7.8) | 0.47 |
| HR (b/min) | 99 (9.5) | 100 (17) | 101 (17) | 99 (13) | 95 (14) | 99 (16) | 95 (13) | 97 (15) | 98 (18) | 100 (23) | 116 (12) | 118 (19) | 116 (18) | 114 (16) | 116 (18) | 114 (17) | 114 (16) | 125 (19) | 0.01 |
| PIP (cm H2O) | 13 (4.6) | 21 (3.4) | 21 (3.2) | 22 (3.3) | 22 (3.7) | 22 (3.7) | 22 (3.9) | 22 (4.0) | 20 (3.0) | 14 (2.7) | 25 (6.0) | 25 (3.1) | 24 (3.6) | 23 (3.4) | 23 (3.6) | 23 (3.3) | 23 (3.8) | 20 (2.8) | 0.21 |
| MAWP (cm H2O) | 4 (.97) | 5.9 (1.2) | 5.7 (.48) | 5.7 (.82) | 5.6 (.69) | 5.7 (1) | 5.9 (.99) | 5.9 (.99) | 5.5 (.85) | 4.5 (.97) | 6.7 (1.5) | 6.4 (1.4) | 6 (.81) | 5.8 (.78) | 6 (.81) | 6 (.66) | 5.9 (.87) | 5.6 (1) | 0.4 |
| PaCO2 (mm Hg) | 39 (4.0) | 46 (8.2) | 44 (3.8) | 45 (3.5) | 46 (3.9) | 46 (4.0) | 45 (2.5) | 47 (3.2) | 48 (5.7) | 37 (5.9) | 51 (8.7) | 44 (6.6) | 44 (3.7) | 46 (5.5) | 44 (4.6) | 44 (4.1) | 43 (3.7) | 46 (6.3) | 0.62 |
| TV (ml) | 97 (7.6) | 94 (7.4) | 93 (9.5) | 93 (6.4) | 92 (7.4) | 95 (6.8) | 96 (6.5) | 96 (6.2) | 95 (6.5) | 90 (9.3) | 87 (13.1) | 91 (7.4) | 90 (8.5) | 88 (8.1) | 89 (5.2) | 89 (6.1) | 91 (6.3) | 89 (10.2) | 0.1 |
| RR (/min) | 18 (4.5) | 20 (5.6) | 17 (5.0) | 17 (5.0) | 17 (4.1) | 18 (4.8) | 17 (4.3) | 17 (4.4) | 18 (3.9) | 17 (3.4) | 19 (3.3) | 19 (2.6) | 19 (4.8) | 21 (5.7) | 20 (4.4) | 19 (4.5) | 20 (5.1) | 20 (4.4) | 0.12 |
ANOVA = analysis of variance, BL = baseline, HR = heart rate, MAP = mean arterial pressure, PIP = positive inspiratory pressure, MAWP = mean airway pressure, TV = tidal volume, RR = respiratory rate