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Secretory responses of CFT1 (ΔF508), CFT1-LC3 (βgal), and CFT1-LCFSN (wild-type CFTR) cells. Relative changes in cell volume after the addition of 10 μM isoproterenol (A, C, and E) or 100 μM ATP (B, D, and F) to the solution bathing CFT1 (A and B), CFT1-LC3 (E and F), and rescued cells (CFT1-LCFSN) expressing wild-type CFTR (C and D). Volume was measured as described in Methods. The agonists were added at time = 0 min and remained in the bath for the duration of the experiment.
