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The PDE genes of the kinetoplastids. A, domain structures of the four PDE families that are present in all currently sequenced kinetoplastid genomes (T. brucei, T. cruzi, T. vivax, T. congolense, T. evansi, Crithidia fasciculata, Leishmania tarentolae, L. major, L. braziliensis, L. mexicana, and L. infantum). B, domain structures of PDECs from various kinetoplastid species. Cross-hatched bars, FYVE-type domains; gray bars, coiled-coil regions; black bars, catalytic domains.
