TABLE 2.

Kinetic constants for reactivation of paraoxon-, sarin-, cyclosarin-, VX- and tabun-hAChE conjugates by principal uncharged lead oxime RS194B initial lead RS41A, several oximes leading from RS41A to RS194B, and reference oximes 2PAM, MINA, and DAM

Maximal reactivation rate constant (k₂, min⁻¹), apparent dissociation constant of [oxime · OP-hAChE conjugate] reversible complex (K_ox, mm), and overall second order reactivation rate constant (k_r, m⁻¹ min⁻¹) were determined from reactivation curves as presented in Fig. 2. All constants were determined from triplicate experiments. S.E. of determined kinetic constants were typically less than 30% that of the mean.