TABLE 6.

Combination of therapy and pretreatment of OP-exposed mice with oxime RS194B at doses equivalent to 25, 10, or 5% its LD₅₀ dose of 500 mg/kg (cf.supplemental Tables S2–S6)

Protective index is the ratio of OP LD₅₀ for OP-exposed animals treated with oxime and for animals given OP alone. Maximal dose of poison (MDP), a highest multiple of OP LD₅₀ fully counteracted by the oxime, is given in parentheses. Oximes in therapy (but not in pretreatment) were administered together with atropine. ND, not determined.

RS194B	Protective index (MDP) (95% confidence limits)
	Pretreatment before VX		Therapy 1 min after VX	Pretreatment 15 min and therapy 1 min after VX
	5 min	15 min
25 mg/kg	2.0 (1.6)	1.6 (ND)	5.3 (4)
	(1.8–2.3)	(1.2–2.1)	(4.8–6.0)
50 mg/kg		1.3 (1.0)	11 (7.9)	7.3 (5.0)
		(1.1–1.6)	(8.5–13.7)	(5.6–9.6)
125 mg/kg	3.7 (2.5)	3.6 (2.5)	18 (10.0)	45 (31.8)
	(2.9–4.7)	(3.0–4.2)	(12.4–25.7)	(37.2–54.3)

	Pretreatment 15 min and therapy 1 min after OP
	Paraoxon	Soman	Tabun	Sarin
125 mg/kg	22 (7.9)	2.8 (2.5)	2.0 (ND)	4.5 (3.2)
	(17.0–27.5)	(ND)	(1.3–3.1)	(3.8–5.3)