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Microtubule-targeting drugs do not inhibit HIF-1α translation in RCC cells. A–D, HIF-1α immunoblot in different RCC cell lines, following the indicated MTD treatments in normoxia or 4 h hypoxia. E, polysome association profile of HIF-1α mRNA from RCC2 cells treated with 100 nm or 1 μm TX. The percent of HIF-1α mRNA associated with actively translating polysomes (gray bars) or non-translating ribosomal subunits (black bars) is plotted as mean ± S.D.
