FIGURE 4.

Structure of the Ig-PH domain. A, ribbon representation of the Ig-PH domain. The Ig and PH domains are colored wheat and green, respectively. The secondary structures are labeled. B, the omit electron density map contoured at the 1.5σ level is shown for the malonate-binding site. C, the conservation surface as shown in three orientations. The lower right structure is oriented as in A. The Ig and PH domains are colored wheat and green, respectively. The residues at least 80% conserved are colored yellow. D, interactions between the Ig and PH domains. Hydrogen bonds are denoted by dotted lines.