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. 2012 Feb 15;287(15):12111–12120. doi: 10.1074/jbc.M111.327023

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — N-CoR regulates HDAC3 stability. A, Western blot analysis of the expression of indicated proteins in FLAG-HDAC3-expressing HeLa cells transduced with the indicated shRNAs. B, pulse-chase assays detecting the turnover rate of FLAG-HDAC3 in FLAG-HDAC3-expressing HeLa cells transduced with the indicated shRNAs. Left panel, autoradiography of immunoprecipitated FLAG-HDAC3 obtained using anti-FLAG M2 agarose at 0-h and 4-h time points. Right panel, quantification of the immunoprecipitated FLAG-HDAC3 shown on the left panel. C, Western blot analysis of the expression of indicated proteins in normal HeLa cells and in HeLa cells stably expressing FLAG-tagged mouse N-CoR protein. These cells were transduced with control shRNA or human N-CoR-specific shRNA.