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. 2012 Feb 20;287(15):12241–12249. doi: 10.1074/jbc.M111.293613

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — Obese mice with elevated noggin have reduced bone mineral density. A, femurs and tibiae from normal and obese mice were used for micro-CT analysis of trabecular bone. A representative image is shown. B, histology of bone sections for femur and tibia from normal and obese mice after hematoxylin and eosin staining are shown. Various parameters such as trabecular number (1/mm) (C), trabecular speciation (mm) (D), and bone volume/total volume (E) were analyzed based on micro-CT data. Data are representative of micro-CT analysis from three different mice (n = 3; *, p < 0.05).