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WRN and DNA Pol δ co-operate to degrade bubble and X-junction DNA. WRN (50 fmol) and DNA Pol δ (60 fmol) were preincubated on ice for ∼2 min either separately or together as indicated. Reactions were initiated by the addition of DNA and incubated and processed as described above. The band intensities of exonucleolytic DNA products, obtained using ImageJ software, are plotted to better illustrate synergism between WRN and Pol δ exonucleases. A, bubble DNA. B, four-way junction DNA.
