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Synergism between WRN and Pol δ exonucleases is independent of DNA unwinding. WRN (20 fmol) and Pol δ (45 fmol) were incubated either individually or together with bubble DNA in reactions lacking ATP or containing the helicase minus WRN variant, K577M, as indicated. Exonucleolytic digestion of DNA was compared with control reactions with ATP.
