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The p12 subunit of Pol δ is dispensable for exonuclease synergism with WRN. Reactions with bubble DNA were carried out as described, except that the 4-subunit Pol δ holoenzyme was replaced with either the S. cerevisiae (A) or human (B) 3-subunit Pol δ complex that lacks the p12 subunit. Lanes 1 and 2 refer to 0.5 and 1.0 fmol of S. cerevisiae Pol δ or 10 and 40 fmol of human Pol δ, respectively; WRN was used at 6 fmol per reaction.
