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. 2001 Apr 24;98(9):5335–5340. doi: 10.1073/pnas.091239098

Figure 1.

Figure 1

Drug-sensitive IKr current in control guinea-pig ventriculocytes compared with myocytes that were infected in vivo with AdEGI-HERG or AdEGI-HERG-G628S. Original current traces of the drug-sensitive IKr (A) and pooled data of drug-sensitive IKr tail current density (B) (recorded with 200-ms depolarization pulses to 40 mV followed by repolarization to −50 mV) demonstrate that enhanced expression of HERG (gray bars) significantly increased IKr compared with noninfected myocytes (black bars), whereas in vivo expression of HERG-G628S (white bars) suppressed IKr tail current density.