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. 2012 Feb 21;287(15):12541–12549. doi: 10.1074/jbc.M111.332130

FIGURE 1.

FIGURE 1.

Vascular reactivity of wild type and RGS2-deficient MA. A, vasoconstriction of WT and RGS2−/− MA to PE (n = 6–10 animals (2 vessels/animal) per group). The data shown are the mean percentages of change in diameter of arteries superfused with MOPS containing PE at indicated concentrations. The data are expressed as the percentages of change in vessel diameter relative to base line. B, vasodilatation of WT and RGS2−/− MA to the NO donor, SNP, following constriction with PE. The data are expressed as percentages of diameter increase. C, changes in WT and RGS2−/− arterial diameter after application of PE and increasing concentrations of ACh. D, concentration response of ACh-induced vasodilation expressed as percentages of increase in arterial diameter after constriction with PE (100 μmol/liter). The data are expressed as the means ± S.E. **, p < 0.01 versus WT (two-way analysis of variance).