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. 2012 Feb 21;287(15):12541–12549. doi: 10.1074/jbc.M111.332130

FIGURE 2.

FIGURE 2.

Effect of endothelin ETA receptor and cyclooxygenase blockade on ACh-induced vasodilatation of WT and RGS2-deficient MA. A, vasodilatation of WT (n = 5) and RGS2−/− (n = 6) MA to ACh in the presence or absence of the ETA receptor antagonist, BQ123 (5 μmol/liter). B, vasodilatation of WT (n = 6) and RGS2−/− (n = 6) MA incubated with or without indomethacin (10 μmol/liter). The data shown are the percentages of change in vessel diameter ± S.E. after application of increasing concentrations of ACh in the presence of 100 μmol/liter PE.