Effect of eNOS and EDHF inhibitors on ACh-induced vasodilatation of WT and RGS2−/− MA.
A, ACh-induced vasodilatation of WT and RGS2−/− MA in the presence (WT, n = 7; RGS2−/−, n = 7) and absence (WT, n = 10; RGS2−/−, n = 10) of eNOS inhibitor, l-NAME (500 μmol/liter). B, vasodilatation of WT and RGS2−/− MA in the presence (WT, n = 4; RGS2−/−, n = 5) and absence (WT, n = 8; RGS2−/−, n = 8) of EDHF inhibitors, apamin (50 nmol/liter) and Tram-34 (1 μmol/liter). The data are the means ± S.E. **, p < 0.01 versus WT and RGS2−/− controls, respectively.