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. 2012 Feb 21;287(15):12541–12549. doi: 10.1074/jbc.M111.332130

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Vascular reactivity of wild type and endothelium-specific RGS2-deficient MA. A, changes in WT (Tie2-CreER^T2 + tamoxifen) (n = 6) and RGS2^EC−/− (Tie2-CreER^T2/RGS2^fl/fl + tamoxifen) (n = 5) arterial diameter after application of PE and increasing concentrations of ACh as indicated. B, concentration response of ACh-induced vasodilatation in A expressed as percentages of increase in arterial diameter after application of PE (100 μmol/liter). C, vasoconstriction of WT and RGS2^EC−/− MA to phenylephrine. D, vasodilatation of WT and RGS2^EC−/− MA to SNP, following constriction with PE. The data are expressed as the means ± S.E. **, p < 0.01 versus WT (two-way analysis of variance).