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Vasodilatory responses of control and smooth muscle-specific RGS2-deficient MA. A, concentration response of ACh-induced vasodilatation in WT (SMMHC-CreERT2 + tamoxifen) (n = 5) and RGS2SM −/− (RGS2SM −/−: SMMHC-CreERT2/RGS2fl/fl + tamoxifen) (n = 6) MA expressed as percentages of increase in arterial diameter after application of PE (100 μmol/liter). B, vasodilatation of WT and RGS2SM −/− MA to SNP, following constriction with PE. The data are expressed as the means ± S.E.
