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Model for SAMHD1 recruitment to CRL4DCAF1-Vpx. The N terminus of Vpx interacts with the C-terminal region of SAMHD1 and recruits SAMHD1 to CRL4DCAF1-Vpx E3 ubiquitin ligase for ubiquitination. The relative positioning of the individual subunits in the CRL4DCAF-Vpx complex is based on the known architecture of CRL4 E3 ubiquitin ligases (44).
