Table 3. Functions of genes with differential methylation between acute lymphoblastic leukemia cells and normal bone marrow cells.
| Gene symbola | Gene name | Cellular functionb |
| ACCS | 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional) | biosynthetic process |
| ACY3 | aspartoacylase (aminocyclase) 3 | metabolic process |
| AMICA1 | adhesion molecule, interacts with CXADR antigen 1 | cell-to-cell signaling and interaction*, adhesion, leukocyte transmigration |
| CD300LF | CD300 molecule-like family member f | hematological system development and function |
| COL6A2 | collagen, type VI, alpha 2 | apoptosis*, adhesion, cell cycle |
| CPNE7 | copine VII | lipid metabolic process, transport |
| CR1 | complement component (3b/4b) receptor 1 (Knops blood group) | cell death*, cell-to-cell signaling and interaction*, adhesion, hematological system development and function |
| DBC1 | deleted in bladder cancer 1 | cell death*, cell cycle |
| EYA4 | eyes absent homolog 4 (Drosophila) | cell death* |
| FAM83A | family with sequence similarity 83, member A | NA |
| FXYD2 | FXYD domain containing ion transport regulator 2 | growth and proliferation |
| LGALS8 | lectin, galactoside-binding, soluble, 8 | cell death*, cell-to-cell signaling and interaction*, adhesion |
| MYBPC2 | myosin binding protein C, fast type | adhesion |
| MYO3A | myosin IIIA | NA |
| PI16 | peptidase inhibitor 16 | NA |
| RUNDC3B | RUN domain containing 3B | NA |
| RYR3 | ryanodine receptor 3 | cell-to-cell signaling and interaction* |
| SEC14L4 | SEC14-like 4 (S. cerevisiae) | transport |
| THSD7A | thrombospondin, type I, domain containing 7A | NA |
| TMEM2 | transmembrane protein 2 | NA |
| UQCRFS1 | ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 | cell death*, cell cycle |
| WDR35 | WD repeat domain 35 | cell death*, cell cycle |
| ZNF462 | zinc finger protein 462 | NA |
| ZNF502 | zinc finger protein 502 | NA |
a
Gene symbol according to the HUGO Gene Nomenclature Committee (http://www.genenames.org/).
b
According to Ingenuity Pathway Analysis (IPA);
*
indicates enriched cellular function P<0.05; NA indicates undefined cellular function.