Table 7. Pathway involvement of the hub-node proteins in the context specific network generated by CPNM in Case Study I using pathway information given in hiPathDB database [61].
| Pathway ID | Pathway Name | Total Interactions | Source | Participating proteins from CPNM | Asthma association based on references provided in pathway annotation in the sources. |
| pid_p_200014_il4_2pathway | IL4-mediated signaling events | 62 | Nci-Nature | IL4,IL10,STAT6 | No documented association. |
| path:hsa04630 | Jak-STAT signaling pathway | 9 | KEGG | STAT6 | Part of KEGG asthma pathway. |
| pid_p_200036_nfat_tfpathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | 8 | Nci-Nature | IL4 | PMID: 12452838 |
| pid_p_100157_gata3pathway | gata3 participate in activating the th2 cytokine genes expression | 7 | BioCarta | IL4,IL13 | Association with asthma documented in pathway annotation. |
| path:hsa04060 | Cytokine-cytokine receptor interaction | 5 | KEGG | IL4,IL13,IL10,TSLP | Part of KEGG asthma pathway. |
| pid_p_200070_reg gr_pathway | Glucocorticoid receptor regulatory network | 5 | Nci-Nature | IL4,IL13 | No documented association. |
| path:hsa05140 | Leishmaniasis | 4 | KEGG | IL4,IL10 | No documented association. |
| pid_p_200031_l12_2pathway | IL12-mediated signaling events | 3 | Nci-Nature | STAT6,IL4 | No documented association. |
| path:hsa05142 | Chagas disease | 2 | KEGG | IL10 | No documented association. |
| pid_p_100134_il10pathway | il-10 anti-inflammatory signaling pathway | 2 | BioCarta | IL10 | No documented association. |
| pid_p_200027_cd40_pathway | CD40/CD40L signaling | 2 | Nci-Nature | IL4 | No documented association. |
| pid_p_200182_il_2_stat4pathway | IL12 signaling mediated by STAT4 | 2 | Nci-Nature | IL4,STAT6 | No documented association. |
| pid_p_200002_smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling | 1 | Nci-Nature | IL10 | No documented association. |
| pid_p_200148_il2_stat5pathway | IL2 signaling events mediated by STAT5 | 1 | Nci-Nature | IL4 | No documented association. |
| pid_p_200149_tcrcalciumpathway | Calcium signaling in the CD4+ TCR pathway | 1 | Nci-Nature | IL4 | No documented association. |
| Downstream_signal_transduction | Downstream signal transduction | 1 | Reactome | STAT6 | No documented association. |
| Peptide_ligand_binding_receptors | Peptide ligand-binding receptors | 1 | Reactome | GRP | No documented association. |
Highlighted in bold are the pathways that are known to be associated with asthma as per annotation provided in the source databases in hiPathDB.