Table 1. The effect of serial passages in a constant concentration of isoniazid (0.1 µg/ml) on the INH MIC and the number of days required for detection of growth.
| INH MIC (µg/ml) (days required for detection of growth) | |||||||
| #0 | #1 | #2 | #3 | #5 | #13 | #26 | |
| Fully susceptible strains | |||||||
| H37Rv INH (a) | 0.05 (-) | 128 (19) | 128 (5) | 128 (4) | 128 (4) | 128 (4) | 128 (4) |
| H37Rv INH (b) | 0.05 (-) | 128 (14) | 128 (8) | 128 (5) | 128 (3) | 128 (3) | 128 (3) |
| 401/06 INH (a) | 0.1 (-) | 256 (20) | 256 (6) | 256 (4) | 256 (4) | 256 (4) | 256 (3) |
| 401/06 INH (b) | 0.1 (-) | 64 (32) | 256 (14) | 256 (18) | 256 (7) | 256 (4) | 256 (3) |
| Rifampicin monoresistant strains | |||||||
| 267/05 INH (a) | 0.1 (-) | 128 (15) | 128 (7) | 128 (4) | 128 (6) | 128 (3) | 128 (3) |
| 267/05 INH (b) | 0.1 (-) | 128 (17) | 128 (5) | 128 (4) | 128 (7) | 128 (4) | 128 (3) |
| 359/03 INH (a) | 0.05 (-) | 256 (18) | 256 (13) | 256 (6) | 256 (4) | 256 (4) | 256 (3) |
| 359/03 INH (b) | 0.05 (-) | 128 (17) | 256 (16) | 256 (3) | 256 (3) | 256 (8) | 256 (3) |
Legend: INH: isoniazid; RIF: rifampicin; INH (a)/(b): adaptation processes to isoniazid A and B, respectively.