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. 2012 Apr 6;7(4):e34442. doi: 10.1371/journal.pone.0034442

Table 3. Selected SNPs suggestively associated with hypothyroidism.

SNP Chr. Pos. Region Alleles MAF HWE Inline graphic Inline graphic-value OR
rs1472565 1 19,627,617 CAPZB T/C 0.478 0.39 39249 Inline graphic 1.107 (1.05–1.16)
rs4704397 5 76,554,198 PDE8B G/A 0.390 0.98 21622 Inline graphic 1.179 (1.10–1.26)
rs231779 2 204,442,732 CTLA4 C/T 0.366 0.81 39254 Inline graphic 1.126 (1.07–1.19)

Three SNPs with connections to other conditions that are suggestively associated with hypothyroidism. CAPZB and PDE8B have been associated with TSH levels and CTLA4 with a variety of autoimmune diseases, including autoimmune hypothyroidism. See Table 2 for nomenclature, Table S1 for all SNPs with Inline graphic and Table S2 for 107 SNPs involved in autoimmune disease.