Table 2.

Estimated effect of smoking on incident AD age <75 years (n=751) and for age ≥75 years (n=491) with and without adjustment for competing risks.

Model	Age stratum	Cox model HR† (95% CI)	Competing risks model SHR† (95% CI)
Model 1: include smoking status only	65-74	0.79 (0.39, 1.58)	0.75 (0.37, 1.49)
	≥75	0.32 (0.10, 0.99)	0.48 (0.26, 0.86)
Model 2*: include smoking status, and other baseline covariates	65-74	0.82 (0.41, 1.68)	0.75 (0.37, 1.53)
	≥75	0.37 (0.17, 1.17)	0.53 (0.29, 0.97)
Model 3**: include smoking status, and other baseline covariates, and vascular risk factors	65-74	0.88 (0.39, 2.00)	0.87 (0.38, 1.99)
	≥75	0.20 (0.03, 1.45)	0.34 (0.11, 1.05)

^*Baseline covariates included age at baseline (wave 2), gender, education, use 3 or more prescription drugs, lipid-lowering drug use, NSAID use, >5 depressive symptoms, self-reported health, and number of drinks.

^**APOE ε4 carrier (determined at wave 3); vascular risk factors (measured at wave 3) included history of stroke, myocardial infarction, diabetes, hypertension, and high cholesterol.

^†HR: hazard ratio; SHR: subdistribution hazard ratio.