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. Author manuscript; available in PMC: 2013 Apr 15.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Feb 20;22(8):2997–3000. doi: 10.1016/j.bmcl.2012.02.027

Scheme 3.

Scheme 3

Reagents and conditions. a) LiOH, H2O, DME; b) TBSCl, Imidazole, DMF; c) MeOH, 75% over 3 steps; d) 11, EDCI, HOBt, DIPEA, DMF, 88%; g) TBAF, THF, 95%.