Table 1.
Potencies of 1–5 for inhibiting production of Aβ42.
| compound | Aβ42 IC50 (nM) (HeLa membranes) | Aβ42 IC50 (nM) (CHO-APP) |
|---|---|---|
| 1 | 0.3 | 36 |
| 2 | 1.0 | 817 |
| 3 | 0.3 | 30 |
| 4 | 2.3 | 1000 |
| 5 | 0.2 | 4.0 |
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