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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Neurobiol Aging. 2011 Dec 14;33(6):1121.e13–1121.e24. doi: 10.1016/j.neurobiolaging.2011.11.003

Figure 1. Acute inhibition of KGDHC activity with CESP in N2a neuroblastoma (A) and neurons cultured from embryos (B).

Figure 1

Cells on 24-well plates were incubated with KGDHC reaction mixture containing CESP (0, 10, 50 and 100 μM) for one hr at room temperature and in situ KGDHC was measured as described in Methods. The CESP structural analogue DESP had no effect on KGDHC (Bunik et al, 2005) (data not shown). Panel A is data from N2a cells (2 × 104 cells/well). Panel B has results from neurons cultured from embryos (2× 105 cells/well). Values (percent of control) are the means ± S.E.M. (n=8~10). *** Denotes significantly different (p<0.005) from control.