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. Author manuscript; available in PMC: 2013 Apr 15.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Feb 23;22(8):2976–2979. doi: 10.1016/j.bmcl.2012.02.045

Table 1.

Comparisons of IC50s for P. falciparum growth.

graphic file with name nihms360127u1.jpg
compd n R IC50 (nM) Log Da MWb
2a 9 Me >10,000 −0.08 362.5
2b 3 Ph 3,500 0.01 464.5
2c 5 Ph 1021 ± 93.2 1.14 492.6
2d 9 4-PhF 345.6 ± 15.3 2.13 602.6
2e 9 Bn 288.5 ± 35.2 1.37 590.8
2f 9 n-Bu 194.2 ± 3.8 3.68 488.7
2g 9 Ph 172.7 ± 4.0 1.67 548.7
2h 9 2-PhMe 143.4 ± 7.0 −0.75 590.8
2i 9 C6H11 140.6 ± 0.7 4.50 566.8
2j 9 4-PhOMe 134.0 ± 1.7 3.19 638.7
CQ 66.93 ± 2.3 319.9
a

measured by 1-octanol–water partition at pH 7.4

b

molecular weights of lipocations 2 minus the counterion