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. 2012 Feb 14;31(7):1811–1822. doi: 10.1038/emboj.2012.28

Figure 7.

Figure 7

Model for the regulation of G1/S genes by genotoxic stress. (A) The transcription of MBF-regulated genes is inactivated as cells progress through S phase by Nrm1 binding to their promoters. In response to genotoxic stress, Rad53 is activated and phosphorylates Nrm1, impeding its binding and allowing the expression of MBF genes to be maintained. (B) SBF-regulated genes are inactivated by B-type cyclin/CDK activity in S phase. In response to genotoxic stress, cells continue to have B-type cyclin/CDK activity and, thus, SBF-regulated genes are inactivated in a regular manner.