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. 2012 Feb 21;31(7):1654–1665. doi: 10.1038/emboj.2012.30

Figure 3.

Figure 3

Bourgeonal does not activate a cAMP-signalling pathway. (A) Changes in total cAMP concentration in human sperm bathed in high (25 mM) bicarbonate (HCO3−) evoked by (in mM): 50 HCO3−, 0.5 IBMX; (in μM) 50 bourgeonal, and 50 adenosine (5 measurements from 2 donors). The red lines indicate the 95% confidence intervals (CIs). Overlapping CIs indicate that there is no significant difference between conditions. (B) cAMP changes in sperm bathed in low (4 mM) bicarbonate evoked by (in mM): 50 HCO3−, 0.5 IBMX; (in μM) 50 bourgeonal,50 adenosine, 30 chloro-adenosine, 500 SQ22536, 100 MDL12330A; (in nM) 100 FPP, 10 angiotensin II, 1.5 calcitonin (5–133 measurements from 4 to 16 donors). Data comprise data from Strünker et al (2011) combined with data from additional experiments.