Table 2. Histological features of Mycosis Fungoides (MF; n=38), suspicious for mycosis Fungoides (n=20) and non mycosis Fungoides (n=8) with sensitivity, specificity, positive predictive value, negative predictive value and likelihood ratio.
| Histological parameters | Patch MF (n=38) | Suspicious for MF (n=20) | Non MF (n=8) | p value‡ | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) |
NPV (95% CI) |
LR+ (95% CI) |
LR- (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|
| Epidermotropism | 11 | 0 | 0 | 0.08 | 28.9 (15.4-5.90) |
100 (63.1-100) |
100 (71.5-100) |
22.9 (10.4-40.1) |
- | 0.7 (0.6-0.9) |
| Spongiosis | 10 | 4 | 4 | 0.19 | 26.3 (13.4-43.1) |
50.0 (15.7-84.3) |
71.4 (41.9-91.6) |
12.5 (3.5-29.0) |
0.5 (0.2-1.3) |
1.5 (0.7-3.0) |
| Parakeratosis | 8 | 0 | 1 | 0.58 | 21.1 (9.6-37.3) |
87.5 (47.3-99.7) |
88.9 (51.8-99.7) |
18.9 (7.9-35.2) |
1.7 (0.2-11.6) |
0.9 (0.7-1.2) |
| Dermal Fibrosis | 23 | 14 | 8 | 0.03 | 60.5 (43.4-76.0) |
0 (0.0-36.9) |
74.2 (55.4-88.1) |
0 (0.0-21.8) |
0.6 (0.5-0.8) |
- |
| Intensity of Dermal Infiltrate | 27 | 14 | 6 | 0.82 | 71.1 (54.1-84.6) |
25.0 (3.2-65.1) |
81.8 (64.5-93.0) |
15.4 (1.9-45.4) |
0.9 (0.6-1.5) |
1.2 (0.3-4.3) |
| Location of Dermal Infiltrate | 37 | 18 | 7 | 0.21 | 97.4 (86.2-99.9) |
12.5 (0.4-52.7) |
84.1 (69.9-93.4) |
50.0 (1.3-98.7) |
1.1 (0.9-1.5) |
0.2 (0.01-3.0) |
| Atypical Lymphocytes | 20 | 7 | 3 | 0.44 | 52.6 (35.8-69.0) |
62.5 (24.5-91.5) |
87.0 (66.4-97.2) |
21.7 (7.5-43.7) |
1.4 (0.5-3.6) |
0.8 (0.4-1.4) |
| Hyperconvoluted Epidermal Lymphocytes | 37 | 13 | 4 | 0.002 | 97.4 (86.2-99.9) |
50.0 (15.7-84.3) |
90.2 (76.9-97.3) |
80.0 (28.4-99.5) |
2.0 (1.0-3.9) |
0.1 (0.01-0.4) |
| Hyperconvoluted Dermal Lymphocytes | 31 | 7 | 2 | 0.001 | 81.6 (65.7-92.3) |
75.0 (34.9-96.8) |
93.9 (79.8-99.3) |
46.2 (19.2-74.9) |
3.2 (1.0-10.9) |
0.3 (0.1-0.5) |
| Mitoses | 1 | 0 | 0 | 1.0 | 2.6 (0.1-13.8) |
100 (63.1-100) |
100 (2.5-100) |
17.8 (8.0-32.1) |
- | 1.0 (0.9-1.0) |
| Pautrier’s Micro abscess | 24 | 1 | 1 | 0.05 | 63.2 (46.0-78.2) |
87.5 (47.3-99.7) |
96.0 (79.6-99.9) |
33.3 (14.6-57.0) |
5.1 (0.8-32.1) |
0.4 (0.3-0.7) |
| Grandiosity sign | 24 | 13 | 2 | 0.05 | 63.2 (46.0-78.2) |
75.0 (34.9-96.8) |
92.3 (74.9-99.1) |
30.0 (11.9-54.3) |
2.6 (0.7-8.6) |
0.5 (0.3-0.9) |
| Basal alignment of neoplastic lymphocytes of neoplastic lymphocytes of neoplastic lymphocytes | 33 | 11 | 4 | 0.02 | 86.8 (71.9-95.6) |
50.0 (15.7-84.3) |
89.2 (74.6-97.0) |
44.4 (13.7-78.8) |
1.7 (0.9-3.5) |
0.3 (0.1-0.8) |
| Plasma Cells | 1 | 1 | 1 | 0.21 | 2.6 (0.1-13.8) |
87.5 (47.3-99.7) |
50.0 (1.3-98.7) |
15.9 (6.6-30.1) |
0.2 (0.01-3.0) |
1.1 (0.9-1.5) |
| Eosinophils | 1 | 5 | 1 | 0.21 | 2.6 (0.1-13.8) |
87.5 (47.3-99.7) |
50.0 (1.3-98.7) |
15.9 (6.6-30.1) |
0.2 (0.01-3.0) |
1.1 (0.9-1.5) |
| Adenexal Involvement | 8 | 3 | 1 | 0.58 | 21.1 (9.6-37.3) |
87.5 (47.3-99.7) |
88.9 (51.8-99.7) |
18.9 (7.9-35.2) |
1.7 (0.2-11.6) |
0.9 (0.7-1.2) |
All association and diagnostic tests were done using patch MF and non-MF.
PPV- positive predictive value; NPV-negative predictive value; LR-likelihood ratio; ‡ p-values were obtained using chi-square.