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. Author manuscript; available in PMC: 2013 Mar 29.
Published in final edited form as: Neuroscience. 2012 Jan 4;206:60–68. doi: 10.1016/j.neuroscience.2011.12.040

Figure 3.

Figure 3

Adult mouse MN. The Sigma-1 receptor is found in C-terminals where it colocalizes with potassium channels. A. Sigma-1 Receptor (green) in mouse MN is localized to cholinergic postsynaptic densities juxtaposed to presynaptic boutons positive for choline acetyltransferase labeling (ChAT, red). Scale=10μm (left). The image on the right is a magnified region of the synaptic contact indicated by the arrow in the images on the left. Note that the ChAT positive bouton is adjacent to the Sigma-1 receptor but remains separate. Scale=1μm (right). B. Sigma-1 receptor colocalizes with the Kv2.1channel. In Sigma-1 knockout mice (KO) the distribution of Kv2.1 channels did not appear to change compared to wildtype mice. Scale=20μm. C. In WT mouse MN potassium SK2.2 channels are present in C-terminals and colocalize with Kv2.1 potassium channels. Scale=3μm.