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. Author manuscript; available in PMC: 2012 Apr 8.
Published in final edited form as: Sci Transl Med. 2011 May 18;3(83):83ra40. doi: 10.1126/scitranslmed.3002099

Figure 3. Cilostamide-induced Tregs inhibit IFN-γ production by effector T cells.

Figure 3

(A and B) Frequency of donor-reactive IFN-γ–secreting CD4+ (A) or BM3 (B) T cells per well (mean ± SD; 5-6 mice per group) with representative ELISpot images (left panels) from CBA-Rag−/− mice reconstituted with naive CBA CD25− CD4+ T cells or BM3 CD8+ T cells as effectors with or without ex vivo PDEi-conditioned CBA CD25−CD4+ T cells (Tcilos) transplanted with B6 (H2b) skin allografts. Right panels show the absolute number of IFN-γ positive cells per spleen.