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. Author manuscript; available in PMC: 2012 Apr 8.
Published in final edited form as: Curr Top Membr. 2011;67:79–100. doi: 10.1016/B978-0-12-384921-2.00004-5

FIGURE 3.

FIGURE 3

Summary of the structural basis and the roles of small GTPases in the anterograde trafficking of α2B-AR. The F436, I443/L444, V42, and L48 residues regulate the exit of α2B-AR from the ER and the Y12/S13 residues influence the exit from the Golgi. The small GTPase Sar1 controls α2B-AR export from the ER by modulating the function of the COPII vesicles, whereas ARF1 may be involved in the export of α2B-AR from multiple intracellular compartments including the ER and the Golgi. α2B-AR transport from the ER to the Golgi depends on the normal function of Rab2, but independent of Rab1 and Rab6, and its transport from the Golgi to the cell surface requires Rab8.