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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Bioanalysis. 2012 Jan;4(2):157–166. doi: 10.4155/bio.11.303

Figure 4. Matrix effect of plasma extracts from different sample preparations evaluated via an infusion experiment.

Figure 4

The peak at 2.1 min was lumefantrine. A 10 μg/ml of lumefantrine infused constantly into the LC elute via a ‘T’ joint and directed into MS source while the LC ran at 0.4 ml/min at isocratic mode (65%B). Signal was recorded after injected 10 μl of blank plasma extract from L–L extraction (blue line) and PPt (red line). A 10 μl of 10 μg/ml lumefantrine in mobile phase solvent injected as reference (green line). L–L: Liquid–liquid extraction; PPt: Protein precipitation.