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Proposed sequences that finally induce changes in the long term potentials, which is down regulated in hyperammonemia (modified from Lynch[182]). AMPA: α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; NMDA: N-metil D-aspartato; mGlu: Metabotropic glutamate receptors; PI-3K: Phosphatidylinositol 3-kinases; PKA and PKC: Protein kinase A and C; CaMKII: Ca2+/calmodulin-dependent protein kinases II.
