Table 2.

Plasma lactate levels in B6C3F₁ mice.

AZT dose (mg/kg/d)	Plasma lactate level (mg/dL)
	0-week		12-week
	Male	Female	Male	Female
0	101.4 ± 10.3	126.5 ± 15.4	71.5 ± 1.8a	62.0 ± 3.2a,b
400	100.0 ± 3.7	92.6 ± 9.2	79.3 ± 8.0a	56.0 ± 5.8a,b
500	96.7 ± 3.2	87.5 ± 2.2	57.9 ± 5.2a	56.3 ± 4.2a
600	92.6 ± 4.2	91.2 ± 2.6	65.7 ± 4.3a	52.7 ± 2.3a,b

^aindicates a significant (P < 0.05) difference in plasma lactate levels at 12-week compared to 0-week for each sex.

^bindicates a significant (P < 0.05) sex-related difference in plasma lactate levels in female mice compared to male counterparts at 12-week.

Values are presented as the mean ± SEM (N = 4).