Table III.
MicroRNAs associated with overall survival on a cohort-independent or -dependent manner and supporting independent studies.
| MicroRNA | P-value | Hazard ratio (95% C.I.) | Relevant literature references |
|---|---|---|---|
| hsa-miR-182 | 0.0245 | RX=0: 0.67 (0.57 to 0.77) RX=1: 1.00 (0.71 to 1.38) |
(42)G |
| 0.0027 | CRT=0: 0.66 (0.56 to 0.77) CRT=1: 1.19 (0.83 to 1.69) |
||
| hsa-miR-189 | 0.0316 | 0.12 (0.02 to 0.83) | (45)O |
| hsa-miR-196a | 0.0168 | 1.39 (1.06 to 1.81) | (57)G |
| hsa-miR-221 | 0.0298 | RX=0: 0.67 (0.43 to 1.04) RX=1: 0.41 (0.22 to 0.75) |
(6, 37, 38, 46)G |
| hsa-miR-222 | <0.0001 | 2.14 (1.51 to 3.03) | (6, 37, 38)G |
| hsa-miR-23b | 0.0135 | 1.61 (1.10 to 2.35) | (37)G |
| hsa-miR-26a | 0.0020 | Male: 1.33 (1.02 to 1.71) Female: 2.52 (1.78 to 3.58) |
(37, 40, 41)G |
| hsa-miR-324-5p | <0.0001 | 2.73 (1.80 to 4.14) | (58)G |
| hsa-miR-34c | 0.0106 | 0.62 (0.43 to 0.90) | (52, 53)G |
| ebv-miR-bhrf1-1 | 0.0009 | Other: 0.09 (0.01 to 0.51) Caucasian: 1.83 (1.16 to 2.88) |
(28)O |
| 0.0008 | Male: 0.65 (0.35 to 1.24) Female: 2.77 (1.43 to 5.38) |
||
| hsa-miR-512-3p | 0.0030 | 0.28 (0.12 to 0.65) | (55, 59)O |
| hsa-miR-565 | 0.0996 | Other: 2.97 (1.71 to 5.16) Caucasian: 1.80 (1.41 to 2.30) |
(29)O |
| 0.0003 | Pr/Re=0: 3.80 (2.40 to 6.02) Pr/Re=1: 1.59 (1.27 to 2.00) |
||
| hsa-miR-572 | 0.0691 | 0.76 (0.57 to 1.02) | (60)O |
| hsa-miR-766 | 0.0052 | 1.57 (1.15 to 2.16) | (61)O |
| kshv-miR-k12-1 | <0.0001 | 2.77 (1.78 to 4.31) | (27)O |
| kshv-miR-k12-6-3p | 0.0608 | 1.54 (0.98 to 2.43) | (62)O |
| hsa-miR-101 | 0.0065 | 1.63 (1.15 to 2.32) | (26)G |
| hsa-miR-10b | 0.0146 | RX=0: 1.16 (0.97 to 1.38) RX=1: 0.74 (0.52 to 1.04) |
(6, 42, 43)G |
| hsa-miR-134 | 0.0007 | 2.11 (1.37 to 3.25) | (43)G |
| hsa-miR-137 | 0.0010 | CRN=0: 2.11 (1.45 to 3.05) CRN=1: 0.94 (0.67 to 1.32) |
(30)O |
| hsa-miR-140 | 0.0010 | CRN=0: 0.21 (0.12 to 0.37) CRN=1: 0.65 (0.37 to 1.15) |
(38, 39)G |
| hsa-miR-148a | <0.0001 | 1.65 (1.35 to 2.02) | (63)O |
| hsa-miR-409-3p | 0.0001 | 0.43 (0.28 to 0.66) | (64)O |
C.I., Confidence Interval; RX=1 denotes radiation therapy alone, RX=0 denotes non-RX therapy; CRT=1 denotes chemotherapy plus radiation and targeted therapy, CRT=0 denotes non-CRT therapy; Pr/Re=1 denotes glioblastoma recurrence or progression report, Pr/Re=0 denotes no recurrence or progression report; CRN=1 denotes chemotherapy plus radiation and no targeted therapy, CRN=0 denotes non-CRN therapy;
G
glioblastoma multiforme study;
O
study on any other type of cancer.