Core emerging evidence summary for FTY720 in multiple sclerosis

Outcome measure	Emerging evidence
Patient-oriented evidence
Disease relapse rates	Reduction in relapse rates and time to first relapse Likelihood that patients will at least have longer intervals between relapses
Convenient administration	Daily oral dosing with or without food No dose alterations necessary with hepatic impairment
Tolerability	Well tolerated. No serious adverse events noted. Most common adverse event is asymptomatic, mild, and transient reduction in heart rate No evidence of increased risk of infections associated with drug-related lymphocyte sequestration
Disease-oriented evidence
Disease progression determined by magnetic resonance imaging	Reduction of new and existing inflammatory lesions responsible for subclinical disease progression
Immunomodulation	Reversible lymphocyte sequestration, a characteristic of the mode of action of FTY720, is a convenient surrogate marker of immunomodulation