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. Author manuscript; available in PMC: 2013 Mar 21.
Published in final edited form as: Bioconjug Chem. 2012 Feb 28;23(3):574–585. doi: 10.1021/bc200629f

Scheme 2.

Scheme 2

Self assembly of the multi-functional block graft copolymer 7 into micelle 8, crosslinking into SCK 9, conjugation of Alexa Fluor 633 hydrazide 10, and functionalization with PNAs and TAT to give the final bio-synthetic hybrid nanostructure 13.