Table 4.

Correlation of genome-wide DNA CNAs and acquired mutations or genomic rearrangements with ROSE gene-expression cluster groups

	R1	R2	R3	R4	R5	R6	R7	R8	Total	FET (P)*	Comments
Cases evaluated	20	22	12	13	10	21	76	24	198
1q (gain)†	0	14	1	1	0	0	1	0	17	< .0001	R2 contains TCF3-PBX1
IKZF1	1	0	0	3	3	6	24	22	59	< .0001
CDKN2A/B	4	9	11	11	1	5	40	15	96	< .0001
TCF3	0	14	0	0	2	2	2	0	20	< .0001	R2 contains TCF3-PBX1
ERG	0	0	0	1	0	8	0	0	9	< .0001
VPREB1	0	0	0	5	1	8	23	14	51	< .0001
B-cell pathway	5	17	5	12	4	12	54	23	132	< .0001
B pathway w/VPREB1	5	17	5	12	5	14	56	24	138	< .0001
PAX5	1	9	4	11	0	3	28	7	63	< .0001
EBF1	0	0	0	0	0	0	4	9	13	.0001
TBL1XR1	0	0	3	0	1	1	0	0	5	.0005
NUP160-PTPRJ	0	0	0	0	0	0	0	4	4	.0028
ETV6	1	0	2	2	4	1	14	0	24	.0055
IL3RA-CSF2RA	0	0	0	0	1	0	6	7	14	.0064	High CRLF2 expression
DMD	0	5	1	0	2	3	3	0	14	.0109
C20orf94	0	0	0	1	1	0	7	7	16	.0102
RAG1/2	1	0	0	0	0	0	1	5	7	.0144
ADD3	0	1	0	2	0	0	7	7	17	.0156
NF1	1	1	0	0	2	0	0	1	5	.0269
ARMC2-SESN1	0	2	0	1	2	0	3	5	13	.0297
JAK1 (mutation)	0	0	0	0	0	0	2	1	3	.9448	High CRLF2 expression
JAK2 (mutation)	0	0	0	0	0	0	5	11	16	< .0001	High CRLF2 expression
CRLF2 rearrangement: IGH@-CRLF2	0	0	0	1	0	0	7	11	19	< .0001	High CRLF2 expression
CRLF2 rearrangement: P2RY8-CRLF2	0	0	0	0	0	0	4	7	11	.0041	High CRLF2 expression

^*P values are derived from Fisher exact test.

^†All abnormalities are deletions or chromosomal losses unless otherwise indicated.