Table 1.

Changes in metabolic and renal parameters in WT and TRPV1^−/− mice after 4 weeks of DOCA-salt treatment.

Parameters	WT	TRPV1−/−	DOCA-WTa	DOCA-TRPV1−/−b
BWc (g)	28.8 ± 0.4d	28.2 ± 0.3	29.1 ± 0.5	29.7 ± 0.3
Kidney weight (mg/10 g of BW)	77.1 ± 1.5	76.5 ± 1.2	109.6 ± 3.6e	113.6 ± 3.1e
Urinary albumin (mg/24 h)	6.9 ± 0.8	6.2 ± 0.7	28.3 ± 4.8e	83.7 ± 7.1e,f
GSIg	0.13 ± 0.03	0.09 ± 0.02	0.34 ± 0.04e	0.74 ± 0.08e,f
TISh	0.29 ± 0.10	0.21 ± 0.11	2.00 ± 0.31e	3.14 ± 0.26e,f

^aDOCA-WT, WT mice treated with DOCA-salt.

^bDOCA-TRPV1^−/−, TRPV1^−/− mice treated with DOCA-salt.

^cBW, body weight.

^dValues are mean ± SE (n = 6 to 8).

^eP < 0.05 compared to control WT or TRPV1^−/− mice.

^fP < 0.05 compared to DOCA-WT mice.

^gGSI, glomerulosclerosis index.

^hTIS, tubulointerstitial injury score.