Table 1.

Potential positive and negative aspects of visfatin action in CHC.

Potential negative action	Potential positive action
Increase of TNFα production Stimulation of VCAM-1 synthesis Increase of ICAM-1 synthesis Enhancement of monocytes Stimulation of transmigration and adhesion of macrophages Activation of NF-κB Upregulation of reactive oxygen species Increase of IL-1β synthesis Stimulation of HCC development Enhancement of angiogenesis; increase of VEGF synthesis and activity; increase of VEGF-R2 expression	Improvement of insulin sensitivity Increase of glucose uptake Decrease of glucose release from hepatocytes Increase of MMPs synthesis and activity Inhibition of TIMP synthesis and activity Increase of PPARγ expression and decrease of serum cholesterol level Inhibition of hepatocyte apoptosis Regulation of NAD synthesis Activation of sirtuin-1
Increase of IL-6 synthesis