Figure 2.

Cardiac beneficial effects of M₃-mAChR overexpression against mice myocardial I/R and aconitine injury. (A) Representative electrocardiogram after mice myocardial I/R. The abnormalities include ventricular fibrillation, ventricular tachyarrhythmia, premature ventricular contraction, bigeminy and atrioventricular block. (B) Onset of atrial ventricular block (AVB). (C) Duration of AVB. (D) Arrhythmia score. (E) Mortality after experimental myocardial I/R. *P < 0.05, **P < 0.01 versus WT I/R. (F) Survival time after aconitine-induced arrhythmias in WT and M₃Tg mice. **P < 0.01 versus WT + Aco. Aco, aconitine (5 mg/mL, 2 μg/10 g mice). The average data were presented as mean ± SEM.