Figure 2. The anticocaine monoclonal antibody-induced increase in the cocaine priming threshold.

Each data point represents a priming threshold value measured during one session. Each of a group of six rats contributed ten values, one from each daily session during the ten sessions prior to the infusion of the anticocaine monoclonal antibody 2E2. The cumulative proportion represents the distribution of these priming threshold values (n = 60 measurements, red circles) during the approximately 2-week baseline period. The distribution of the priming threshold values from the same six rats over the 3 days after the infusion of 2E2 are shown (n = 18 measurements, blue circles). The median priming threshold values were 1.1 and 2.7 μmol/kg of cocaine prior to and following the infusion of 2E2, respectively. After 3 days, the magnitude of the priming threshold was lower as the priming threshold values gradually declined towards baseline.

Data presented here are re-analyzed from those presented in [9].