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CDDO and Lon knockdown induce the accumulation of electron dense inclusions within mitochondria. (A) Mitochondria from LonRNAi cells, expressing Lon (control) or knocked down for Lon by doxycycline (DOX) treatment for 2.5 weeks. (B) Mitochondria from Granta cells cultured in the absence (control) or presence of CDDO (2.5μM) for 24 hours.
